Treatment of COVID-19

Medicine that used for the treatment of COVID-19 – Never should miss it !!!

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Medicine or Drugs used for the treatment of COVID-19

In this article I am going to share the Medicine that used for the treatment of COVID-19. But PLEASE DO NOT USE WITHOUT DOCTOR’S PRESCRIPTION. Before learning about the medication and treatment of COVID-19 we should know about the coronavirus.

The second storm of Coronavirus becomes very dangerous and everybody becomes puzzled about the treatment of COVID-19.


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Coronavirus is the illness brought about by a disease of the SARS-CoV-2 infection, first distinguished in the city of Wuhan, in China’s Hubei region in December 2019. Coronavirus was recently known as 2019 Novel Coronavirus (2019-nCoV) respiratory sickness before the World Health Organization (WHO) pronounced the authority name as COVID-19 in February 2020.

Genuine ailment from the contamination is brought about by the beginning of pneumonia and intense respiratory pain disorder (ARDS).

Transmission of COVID-19

The SARS-CoV-2 infection is thought to spread from P2P through:

drop transmission (huge respiratory beads that individuals sniffle, hack or dribble)

airborne transmission (when somebody hacks or wheezes in the room, aerosolized drops from talking and singing)

contact transmission (contacting a debased surface then, at that point contacting your mouth, nose or eyes)

direct transmission (kissing, shaking hands and so forth)

Counteraction should arise for the prevention of COVID-19

The most ideal approach to forestall disease is to keep away from openness to the infection.

⇒ The main method to forestall COVID-19 is to WASH YOUR HANDS.

Washing hands is the best treatment of COVID-19

⇒ Wash your hands routinely and completely with cleanser and water (foam for 20 seconds) OR utilize a liquor based (basically 60%) hand sanitizer.

⇒ Different activities that assistance to forestall the spread of COVID-19:

⇒ stay away from contact with other people who are wiped out

⇒ try not to contact your mouth, nose, eyes or face

⇒ cover hacks and wheezes (into a tissue or into your elbow)

⇒ clean and sanitize surfaces (liquor or blanch based cleaning arrangements turn out best for Covid-19)

⇒ face covers won’t shield you from COVID-19 straightforwardly, yet can assist with diminishing your danger of openness to the infection, remind you to try not to contact your face, and will assist with forestalling the spread of the illness to other people

⇒ social distancing.

self segregation

  • Boosting your safe framework with dietary enhancements (nutrient D, nutrient C, nutrient B complex, quercetin, zinc) may help forestall serious COVID-19.
  • Nutrient D: Good for Your Health, It Might Even Fight COVID-19 January 28, 2021
  • Low Vitamin D Levels Tied to Higher Odds for Severe COVID September 25, 2020

Treatment of COVID-19 : Medicine for the treatment of COVID-19

Whole world are suffering from this coronavirus disease and all scientists are trying to invent some cure to prevent it. Many drugs, medicines and vaccine already has been implemented and suggested by doctors.

Vaccine for the treatment of COVID-19

Remdesivir:
The trade name of Remdesivir is Veklury. This is a broad-spectrum antiviral medication developed by the biopharmaceutical company Gilead Sciences. It is administered via injection into a vein.

The chemical formula of Remdesivir is C27H35N6O8P and Molecular weight is 602.585 g·mol−1

Remdesivir - Medicine for the treatment of Covid-19

During the COVID-19 pandemic, remdesivir was approved or authorized for emergency use to treat COVID‑19 in around 50 countries. Remdesivir was originally developed to treat hepatitis C.

 

Side Effects:
– raised blood levels of liver enzymes
– nausea
– liver inflammation
– infusion-related reaction with nausea,
– low blood pressure, and
– sweating.

 

Bamlanivimab (LY-CoV555)

Bamlanivimab (LY-CoV555) is a monoclonal antibody developed by AbCellera Biologics and Eli Lilly as a treatment for COVID-19.Bamlanivimab is also used as part of the bamlanivimab/etesevimab combination that was granted an EUA by the FDA. The drug was granted an emergency use authorization (EUA) by the US Food and Drug Administration (FDA) in November 2020, In April 2021, the EUA was revoked.

Casirivimab/ Imdevimab

The Trade name of Casirivimab/imdevimab is REGEN-COV. The other name is REGN-COV2. This is an experimental medicine developed by the American biotechnology company Regeneron Pharmaceuticals. It is an artificial “antibody cocktail” designed to produce resistance against the SARS-CoV-2 coronavirus responsible for the COVID-19 pandemic.

Casirivimab/imdevimab acting for the treatment of Covid-19

In Casirivimab, the Monoclonal antibody against spike protein of SARS-CoV-2. In Imdevimab, the Monoclonal antibody against spike protein of SARS-CoV-2.

It consists of two monoclonal antibodies, casirivimab (REGN10933) and imdevimab (REGN10987) that must be mixed together. The combination of two antibodies is intended to prevent mutational escape.It is also available as a co-formulated product.

Bamlanivimab/etesevimab
Etesevimab is a monoclonal antibody against the surface spike protein of SARS‑CoV‑2. Eli Lilly licensed etesevimab from Junshi Biosciences.

Bamlanivimab (LY-CoV555), was granted an emergency use authorization (EUA) by the US Food and Drug Administration (FDA) in November 2020, is a monoclonal antibody developed by AbCellera Biologics and Eli Lilly as a treatment for COVID-19 and In April 2021, the EUA was revoked.

The drug is an IgG1 monoclonal antibody (mAb) directed against the spike protein of SARS-CoV-2. The aim is to block viral attachment and entry into human cells, thus neutralizing the virus, and help preventing and treating COVID-19.

 

Dexamethasone

Dexamethasone is a glucocorticoid medication, was first synthesized in 1957 by Philip Showalter Hench and was approved for medical use in 1961.It is on the World Health Organization’s List of Essential Medicines.

Dexamethasone - Treatment of COVID-19

⇒ Trade names of Dexamethasone are – Dextenza, Ozurdex, Neofordex, others.
⇒ Bioavailability: 80–90%
⇒ Protein binding: 77%
⇒ Metabolism: Liver
⇒ biological half-life: 36 to 54 hours; plasma half-life: 4 to 5 hours
⇒ Chemical Formula: C22H29FO5
⇒ Molar mass: 392.467 g·mol−1
⇒ Melting point 262 °C (504 °F)

This is mainly used to treat rheumatic problems, a number of skin diseases, severe allergies, asthma, chronic obstructive lung disease, croup, brain swelling, eye pain following eye surgery, and along with antibiotics in tuberculosis.

Dexamethasone is suggested by the National Health Service in the UK and the National Institutes of Health (NIH) in the US for patients with COVID-19 who need either mechanical ventilation or supplemental oxygen (without ventilation). Dexamethasone is generally not suggested.

 

The Infectious Diseases Society of America (IDSA) rule board proposes the utilization of glucocorticoids for patients with extreme COVID-19, characterized as patients with SpO2 ≤94% on room air, and the individuals who require supplemental oxygen, mechanical ventilation, or extracorporeal film oxygenation (ECMO). The IDSA advises against the utilization of glucocorticoids for those with COVID‑19 without hypoxemia requiring supplemental oxygen.

The World Health Organization (WHO) suggests foundational corticosteroids as opposed to no fundamental corticosteroids for the treatment of individuals with serious and basic COVID-19 (in number proposal, in view of moderate assurance proof).

The WHO proposes not to utilize corticosteroids in the treatment of individuals with non-serious COVID-19 (contingent suggestion, in light of low sureness proof).

A meta-investigation of seven clinical preliminaries of fundamentally sick COVID-19 patients, each treated with one of three unique corticosteroids discovered a measurably huge decrease in death.[28] The biggest decrease was acquired with dexamethasone (36% contrasted with fake treatment).

 

Safety Hazards of Dexamethasone:
The long-term use of dexamethasone may result in thrush, bone loss, cataracts, easy bruising, or muscle weakness.
It is in pregnancy category C in the United States, meaning that it should only be used when the benefits are predicted to be greater than the risks.
In Australia, the oral use is category A, meaning it has been frequently used in pregnancy and not been found to cause problems to the baby. It should not be taken when breastfeeding. Dexamethasone has anti-inflammatory and immunosuppressant effects.

Hydroxychloroquine and chloroquine

Hydroxychloroquine and chloroquine. These intestinal sickness drugs were approved for crisis use by the FDA during the COVID-19 pandemic.

Hydroxychloroquine

 

 

  • Chemical Formula: C18H26ClN3O
  • Molecular Weight: 335.88 g·mol−1
  • Half-time: 32–50 days
  • Protein Binding: 45%

 

 

 

 

 

 

Notwithstanding, the FDA pulled out that approval when information investigation showed that the medications are not successful for treating COVID-19. They can likewise cause genuine heart issues.

 

Final word for the treatment of COVID-19

Beside taking vaccine for the treatment of COVID-19 everybody should avoid the coronavirus. Because every medicine has some side effects and all medicine are not suitable for all. The best treatment of COVID-19 is the home treatment for the patients who are not in serious condition.

So, if you have face any problem you should call the doctor and get treatment suggested by the doctor.

But It is also seems very good at home for the treatment of Covid-19 patient:

  • Taking hot steam
  • Taking Vitamin-C, D, K (Lemon)
  • Taking proper rest
  • Arranging Oxygen beside the hand (for emergency situation)
  • Physical exercise
  • Breathing exercise.
  • Drinking tea (For ani-oxidants).

Acknowledgements: Data and Image source – WIKIPEDIA

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